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7th Noordwijkerhout Symposium on Pharmacokinetics, Pharmacodynamics and Systems Pharmacology, Noordwijk, 2014

April 23-25, The Netherlands

DDMoRe was running a 2 hours hands-on workshop on Wednesday 23rd April 2014, 10:00 - 12:00 as an introduction to the current functionalities of its new Drug & Disease Model Library and its Modelling and Simulation (M&S) platform. After a general introduction to the DDMoRe initiative, workshop attendees were instructed on the MDL editor practicalities that support the new Modelling Description Language (MDL). The MDL coding for one example, a model on Tumour Growth Inhibition (TGI) in patients with low-grade glioma1, was presented as well as the mechanisms by which third party tools can interact on the interoperability framework via a new exchange language standard for Pharmacometric models (PharmML). The intention was to demonstrate an increased efficiency in applying model-based approaches, exchanging knowledge and thereby positively impacting quantitative decision making in drug-development.  Program outline

·        Introduction to the DDMoRe project

·        Presentation of the tumour growth inhibition (TGI) model

·        Demonstration of current features of the platform, exemplified using the TGI model

·        Q&A

1 Benjamin Ribba, Gentian Kaloshi, Mathieu Peyre, et al. A tumor growth inhibition model for low-grade glioma treated with chemotherapy or radiotherapy. Clin Cancer Res 2012;18:5071-5080.  doi:10.1158/1078-0432.CCR-12-0084 

Associated members

Lutz Harnisch's picture
Lutz Harnisch
Maciej Swat's picture
Maciej Swat
EMBL - European Bioinformatics Institute
Mats Karlsson's picture
Mats Karlsson
Uppsala Universitet
Natallia Kokash's picture
Natallia Kokash
Universiteit Leiden
Nick Holford's picture
Nick Holford
Uppsala Universitet
Wendy Aartsen's picture
Wendy Aartsen
Leiden University
Richard Kaye's picture
Richard Kaye
Mango Solutions

Related links

AAPS - American Association of Pharmaceutical Scientists

ACoP - American Conference on Pharmacometrics

COMBINE - The 'COmputational Modeling in BIology' NEtwork

EARL - EARL conference; effective application of the R language

ISoP - International Society of Pharmacometrics

PAGANZ - Population Approach Group of Australia and New Zealand

PAGE - Population Appraoch Group in Europe

PharmacoMetrica - PharmacoMetrica workshop

PKUK - Pharmacokinetics (UK)

WCoP - World Conference on Pharmacometrics