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PAGE Meeting - Alicante 2014

June 10 - 13, Spain

The 23rd PAGE 2014 meeting was hosted by Miguel Hernandez University and was held in the Cruise Terminal of Alicante.

  1. A diagnostic tool for population models using non-compartmental analysis: The nca functionality for R. Chayan Acharya, Andrew C. Hooker, Siv Jönsson, Mats O. Karlsson
  2. Glucose Homeostasis Modeling: Improvement of the Insulin Kinetics Component. Roberto Bizzotto, Andrea Natali, Amalia Gastaldelli, Ralph A. De Fronzo, Ele Ferrannini, Andrea Mari
  3. A step forward toward personalised medicine in oncology: Population modelling for the early prediction of disease progression using biomarkers. Núria Buil-Bruna, José-María López-Picazo, Marta Moreno-Jiménez, Salvador Martín-Algarra, Benjamin Ribba and Iñaki F. Trocóniz
  4. Pharmacokinetic and Pharmacodynamic analysis of Gemcitabine in pancreatic cancer in mice. Maria Garcia-Cremades, Celine Pitou, Philip W Iversen, Iñaki F Troconiz
  5. Within subject variability in pharmacometric count data modeling analysis: dynamic inter-occasion variability and stochastic differential equations. Chenhui Deng, Elodie L. Plan and Mats O. Karlsson
  6. Sample size calculations in multiple sclerosis using pharmacometrics methodology: comparison of a composite score continuous modeling and Item Response Theory approach. Ana Kalezic, Radojka Savic, Alain Munafo, Elodie Plan, Mats O Karlsson
  7. Evaluation of Mechanism Based PKPD Model for Antibiotics. David Khan, Elisabet I. Nielsen, Pernilla Lagerbäck, Cao Sha, Christer Malmberg, Ulrika Lustig, Erik Gullberg, Otto Cars, Diarmaid Hughes, Dan I. Andersson, Lena E. Friberg
  8. Item response theory for analyzing placebo and drug treatment in Phase 3 studies of schizophren. Elke H.J. Krekels, Ana Kalezic, Lena E. Friberg, An M. Vermeulen, Mats O. Karlsson
  9. Two-stage adaptive designs in nonlinear mixed-effects model: an evaluation by simulation for a pharmacokinetics (PK) and pharmacodynamics (PD) model in oncology. Giulia Lestini, Cyrielle Dumont, France Mentre
  10. PFIM 4.0: new features for optimal design in nonlinear mixed effects models using R. France Mentré, Thu Thuy Nguyen, Giulia Lestini, Cyrielle Dumont and the PFIM group
  11. Simulating large time-to-event trials in NONMEM. Joakim Nyberg, Kristin E. Karlsson, Siv Jönsson, Ulrika S.H. Simonsson, Mats O. Karlsson and Andrew C. Hooker
  12. Tumor growth and angiogenesis inhibition modeling: Effects of pazopanib on preclinical and clinical tumor size data. Aziz Ouerdani, Herbert Struemper, Ben Suttle, Daniele Ouellet and Benjamin Ribba
  13. Modelling of Glucose and Insulin profiles in Patients with Type 2 Diabetes Mellitus treated with a GLP-1 analogue. Rikke M Røge, Søren Klim, Steen H Ingwersen, Maria C Kjellsson, Niels R Kristensen
  14. Steady-state equivalence of drug- and biomarker driven models in tumor growth experiments. M. L. Sardu, I. Poggesi, G. De Nicolao
  15. PKPD-Modeling of individual lesion maximal standardized uptake value (SUV) in Gastro-Intestinal Stromal Tumors (GIST) patients treated with sunitini. Emilie Schindler, Michael Amantea, Mats O. Karlsson, Lena E. Friberg
  16. Are insulin measurements needed in glucose provocation studies? : Comparison of study power using Monte-Carlo Mapped Power (MCMP) method. Siti M. Sheikh Ghadzi, Mats O. Karlsson, Maria C. Kjellsson
  17. PharmML 1.0 - An Exchange Standard for Models in Pharmacometrics. Maciej J Swat, Sarala Wimalaratne, Niels Rode Kristensen
  18. An energy based model able to describe the effect of anticancer drugs on tumor growth and host body weight. N. Terranova, F. Del Bene, M. Germani, M. Rocchetti and P. Magni
  19. Item Response Theory Model as Support for Decision-Making: Simulation Example for Inclusion Criteria in Alzheimer's Trial. Sebastian Ueckert, Andrew C. Hooker, Mats O. Karlsson, Elodie L. Plan

Software demonstration:



Related links

AAPS - American Association of Pharmaceutical Scientists

ACoP - American Conference on Pharmacometrics

COMBINE - The 'COmputational Modeling in BIology' NEtwork

EARL - EARL conference; effective application of the R language

ISoP - International Society of Pharmacometrics

PAGANZ - Population Approach Group of Australia and New Zealand

PAGE - Population Appraoch Group in Europe

PharmacoMetrica - PharmacoMetrica workshop

PKUK - Pharmacokinetics (UK)

WCoP - World Conference on Pharmacometrics