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PODE 2014

September 11, Basel, Germany

10th Basel M&S Seminar, Optimal design strategies in drug development

Dose selection for late clinical stage is one of the key challenges in drug development. This is usually done via conventional designs of dose-ranging studies where different doses are tested against placebo to determine which dose works best. However, for optimal dose selection a robust dose – exposure – response relationship needs to be established in early stage. Such relationship could be characterized using pharmacometric models and optimal designs with informative pharmacokinetic (PK) and pharmacodynamics (PD) data.

The main objective of this Basel M&S meeting is to illustrate with actual examples the use and the value of optimal design approaches, to discuss the current status and limitation of those approaches as well as to identify potential future directions.

The morning meeting will be followed by the annual PODE (Population Optimum Design of Experiments) workshop focusing on the theory of optimum experimental design for non-linear mixed effects models and its applications in drug development (http://www.maths.qmul.ac.uk/~bb/PODE/PODE2014.html).

Several DDMoRe members are presenting DDMoRe related work at this seminar. 

Work package: 
Categories: 

Associated members

Academia
Andrew Hooker's picture
Andrew Hooker
Uppsala Universitet
France Mentré's picture
France Mentré
UPD

Related links

AAPS - American Association of Pharmaceutical Scientists

ACoP - American Conference on Pharmacometrics

COMBINE - The 'COmputational Modeling in BIology' NEtwork

EARL - EARL conference; effective application of the R language

ISoP - International Society of Pharmacometrics

PAGANZ - Population Approach Group of Australia and New Zealand

PAGE - Population Appraoch Group in Europe

PharmacoMetrica - PharmacoMetrica workshop

PKUK - Pharmacokinetics (UK)

WCoP - World Conference on Pharmacometrics