- funded by IMI-JU
- 01 March 2011 - 31 August 2016
- 11 EFPIA members
- 10 Academia and 5 SME's
- Total cost € 23,032,609
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AMT |
Dose amount |
BOV |
Between Occasion Variability (synonym for IOV - Inter-occasion variability) |
CORR |
Correlation |
COV |
Covariance |
CTS |
Clinical Trial Simulation |
CWRES |
Conditional Weighted Residual |
DDMoRe |
Drug Disease Model Resources |
DoW |
Description of Work |
DV |
Dependent Variable |
EFPIA |
European Federation of Pharmaceutical Industries and Associations |
EMA |
European Medicines Agency |
EPS |
Epsilon - Residual Unexplained Variability random effect |
ETA |
Empirical Bayes prediction of the inter-individual random effect in a PK or PD parameter |
FDA |
Food and Drug Administration |
FIS |
Framework Integration Service |
ID |
Individual |
IDV |
Independent variable |
II |
Inter-dose Interval |
IMI |
Innovative Medicines Initiative |
IMI-JU |
Innovative Medicines Initiative Joint Undertaking |
IOF |
Interoperability framework |
IPRED |
Individual Prediction |
IWRES |
Individual Weighted Residual |
MDL |
MDL is the Model Description Language (formerly MCL - Model Coding Language) the human writable and human readable language designed to describe pharmacometric models. |
MDL-IDE |
Modelling Definition Language Integrated Development Environment |
MDV |
Missing Dependent Variable |
MIF |
Mango Integration Framework |
MOG |
Modelling Object Group |
NONMEM |
NONLinear Mixed Effects Modelling (see Names) |
OBS |
Observed (value or data) |
PD |
Pharmacodynamic |
PharmML |
Pharmacometrics Markup Language |
PK |
Pharmacokinetic |
PK/PD |
Pharmacokinetic - Pharmacodynamic modelling |
PRED |
Population Prediction |
PROV-O |
Provenance Ontology |
PsN |
Perl Speaks NONMEM |
RDF |
Resource Description Framework |
RUV |
Residual Unexplained Variability |
sd |
Standard Deviation |
SE |
Standard Error |
SEE |
Stand-alone Execution Environment |
SO |
Standard Output |
TEL |
Task Execution Language. |
TES |
Task Execution Server |
var |
Variance |
VPC |
Visual Predictive Check |
WP |
Work Package |
WRES |
Weighted Residual |
XML |
Extensible Markup Language |
Annotation |
A description attached to a model or element of a model: see RDF triple. |
Bootstrap |
Bootstrap is a tool for calculating bias, standard errors and confidence intervals of parameter estimates. It does so by generating a set of new datasets by sampling individuals with replacement from the original dataset, and fitting the model to each new dataset |
Connector |
A piece of software which enables modelling software to communicate with the interoperability framework |
Converter |
A piece of software which enables translation across languages (e.g. mdl to pharmML |
End-User |
A specific user role with privileges to manage only his/her own jobs queues, etc. |
Extensible Markup Language (XML) |
An open standard for exchanging structured documents and data over the internet that was introduced by the World Wide Web Consortium (W3C). |
Interoperability |
DDMoRe project is to provide the capability to define the model once and then use it across a variety of target software tools. We call this “Interoperability”. |
MDL |
MDL is the Model Description Language (formerly MCL - Model Coding Language) the human writable and human readable language designed to describe pharmacometric models. |
MDL-IDE |
Modelling Definition Language Integrated Development Environment |
Metadata |
Metadata (metacontent) is defined as data providing information about one or more aspects of the data, such as:
|
MLXTRAN |
The language used to define models that are executed with Monolix. |
Monolix |
A software for the analysis of nonlinear mixed effects models |
NM-TRAN |
The language used to define models that are executed with NONMEM. |
NONMEM |
NONLinear Mixed Effects Modelling (see Names) |
Ontology |
An organization of some knowledge domain that is hierarchical and contains all the relevant entities and their relations. |
Pharmacometric Workflow |
Tracking the evolution of a model and associated inferences from initial model to final model, capturing metadata and annotations that will facilitate creation of a run record, audit log, QC and reproducibility of all steps within the workflow. Each step in the Pharmacometric workflow may consist of a Task Workflow which defines the procedural steps required to perform a sequence of tasks for a given model. |
PharmML |
XML based exchange format for encoding of non-linear mixed effect models, trial design and modelling steps used in pharmacometrics. URL: pharmml.org |
R |
R is a free software environment for statistical computing and graphics. |
RDF Triple |
An RDF Triple is a statement which relates one object to another. It is composed of three parts: DDMoRe uses RDF triples to describe models held within the repository, for example: |
Repository |
Another stated aim of the DDMoRe project is to provide a library platform for pre-competitive sharing of models - disease models, drug models etc. We call this library the “Repository”. |
Standard Output (SO) |
Tool-independent exchange format intended for storage of results in standardised form, enabling effective data exchange within complex workflows as well as to support the user in assessing, reviewing and reporting a modelling step. |
Task Execution Service (TES) |
Performs job-management within the Interoperability Framework. |
Task Workflow |
A sequence of tasks and procedural steps which can be captured in a scriptable language, like R, facilitating reproducibility of the outputs for a given set of inputs. |
WinBUGS |
Windows implementation of the BUGS (Bayesian Inference Using Gibbs Sampling) project, concerned with flexible software for the Bayesian analysis of complex statistical models using Markov chain Monte Carlo (MCMC) methods. |