Glossary

Dose amount

Between Occasion Variability (synonym for IOV - Inter-occasion variability)

Correlation

Covariance

Clinical Trial Simulation

Conditional Weighted Residual

Drug Disease Model Resources

Description of Work

Dependent Variable

European Federation of Pharmaceutical Industries and Associations

European Medicines Agency

Epsilon - Residual Unexplained Variability random effect

Empirical Bayes prediction of the inter-individual random effect in a PK or PD parameter

Food and Drug Administration

Framework Integration Service

Individual

Independent variable

Inter-dose Interval

Innovative Medicines Initiative

Innovative Medicines Initiative Joint Undertaking

Interoperability framework

Individual Prediction

Individual Weighted Residual

MDL is the Model Description Language (formerly MCL - Model Coding Language) the human writable and human readable language designed to describe pharmacometric models.

Modelling Definition Language Integrated Development Environment

Missing Dependent Variable

Mango Integration Framework

Modelling Object Group

NONLinear Mixed Effects Modelling (see Names)

Observed (value or data)

Pharmacodynamic

Pharmacometrics Markup Language

Pharmacokinetic

Pharmacokinetic - Pharmacodynamic modelling

Population Prediction

Provenance Ontology

Perl Speaks NONMEM
http://psn.sourceforge.net

Resource Description Framework

Residual Unexplained Variability

Standard Deviation

Standard Error

Stand-alone Execution Environment

Standard Output

Task Execution Language.
The working name within the DDMoRe project for the ddmore R package used to perform tasks with MDL and define pharmacometric workflow.

Task Execution Server

Variance

Visual Predictive Check

Work Package

Weighted Residual

Extensible Markup Language

A description attached to a model or element of a model: see RDF triple.

Bootstrap is a tool for calculating bias, standard errors and confidence intervals of parameter estimates. It does so by generating a set of new datasets by sampling individuals with replacement from the original dataset, and fitting the model to each new dataset

A piece of software which enables modelling software to communicate with the interoperability framework

A piece of software which enables translation across languages (e.g. mdl to pharmML

A specific user role with privileges to manage only his/her own jobs queues, etc.

An open standard for exchanging structured documents and data over the internet that was introduced by the World Wide Web Consortium (W3C).

DDMoRe project is to provide the capability to define the model once and then use it across a variety of target software tools. We call this “Interoperability”.

MDL is the Model Description Language (formerly MCL - Model Coding Language) the human writable and human readable language designed to describe pharmacometric models.

Modelling Definition Language Integrated Development Environment

Metadata (metacontent) is defined as data providing information about one or more aspects of the data, such as:

• Means of creation of the data,
• Purpose of the data,
• Time and date of creation,
• Creator or author of data,
• Placement on a computer network where the data was created,
• Standards used

The language used to define models that are executed with Monolix.

A software for the analysis of nonlinear mixed effects models

The language used to define models that are executed with NONMEM.

NONLinear Mixed Effects Modelling (see Names)

An organization of some knowledge domain that is hierarchical and contains all the relevant entities and their relations.
An ontology is used to define the relationships and objects that are used to define the RDF Triples that describe the data, models and results with a Pharmacometrics Workflow

Tracking the evolution of a model and associated inferences from initial model to final model, capturing metadata and annotations that will facilitate creation of a run record, audit log, QC and reproducibility of all steps within the workflow. Each step in the Pharmacometric workflow may consist of a Task Workflow which defines the procedural steps required to perform a sequence of tasks for a given model.

XML based exchange format for encoding of non-linear mixed effect models, trial design and modelling steps used in pharmacometrics. URL: pharmml.org

R is a free software environment for statistical computing and graphics.
https://www.r-project.org/

An RDF Triple is a statement which relates one object to another. It is composed of three parts:
the subject - the entity we are describing
a predication - the relationship
the object - the description

DDMoRe uses RDF triples to describe models held within the repository, for example:
“MODEL-000034765” “has author” “Lena Friberg”

Another stated aim of the DDMoRe project is to provide a library platform for pre-competitive sharing of models - disease models, drug models etc. We call this library the “Repository”.

Tool-independent exchange format intended for storage of results in standardised form, enabling effective data exchange within complex workflows as well as to support the user in assessing, reviewing and reporting a modelling step.

Performs job-management within the Interoperability Framework.

A sequence of tasks and procedural steps which can be captured in a scriptable language, like R, facilitating reproducibility of the outputs for a given set of inputs.

Windows implementation of the BUGS (Bayesian Inference Using Gibbs Sampling) project, concerned with flexible software for the Bayesian analysis of complex statistical models using Markov chain Monte Carlo (MCMC) methods.
http://www.mrc-bsu.cam.ac.uk/bugs/winbugs/contents.shtml