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Publication in CPT:PSP supported by DDMoRe

Resistance Development: A Major Piece in the Jigsaw Puzzle of Tumor Size Modeling. N Terranova, P Girard, U Klinkhardt and A Munafo CPT: Pharmacometrics & Systems Pharmacology 2015, 4, 320

Abstract
Mathematical models of tumor size (TS) dynamics and tumor growth inhibition (TGI) need to place more emphasis on resistance development, given its relevant implications for clinical outcomes. A deeper understanding of the underlying processes, and effective data integration at different complexity levels, can foster the incorporation of new mechanistic aspects into modeling approaches, improving anticancer drug effect prediction. As such, we propose a general framework for developing future semi-mechanistic TS/TGI models of drug resistance.

Work package: 

Associated members