- funded by IMI-JU
- 01 March 2011 - 31 August 2016
- 11 EFPIA members
- 10 Academia and 5 SME's
- Total cost € 23,032,609
White Paper: Landscape on Technical and Conceptual Requirements and Competence Framework in Drug/Disease Modeling and Simulation.
G Vlasakakis, E Comets, A Keunecke, I Gueorguieva, P Magni, N Terranova, O Della Pasqua, E C de Lange and C Kloft. CPT: Pharmacometrics & Systems Pharmacology 2013, 2, e40
Abstract
Pharmaceutical sciences experts and regulators acknowledge that pharmaceutical development as well as drug usage requires more than scientific advancements to cope with current attrition rates/therapeutic failures. Drug disease modeling and simulation (DDM&S) creates a paradigm to enable an integrated and higher-level understanding of drugs, (diseased)systems, and their interactions (systems pharmacology) through mathematical/statistical models (pharmacometrics)—hence facilitating decision making during drug development and therapeutic usage of medicines. To identify gaps and challenges in DDM&S, an inventory of skills and competencies currently available in academia, industry, and clinical practice was obtained through survey. The survey outcomes revealed benefits, weaknesses, and hurdles for the implementation of DDM&S. In addition, the survey indicated that no consensus exists about the knowledge, skills, and attributes required to perform DDM&S activities effectively. Hence, a landscape of technical and conceptual requirements for DDM&S was identified and serves as a basis for developing a framework of competencies to guide future education and training in DDM&S.
Charlotte Kloft Freie Universität Berlin - FUB |
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Emmanuelle Comets UPD |
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Liesbeth de Lange Universiteit Leiden |
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Paolo Magni Universita' degli Studi di Pavia |
Georgios Vlasakakis GSK |
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Ivelina Gueorguieva Eli Lilly |
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Nadia Terranova ME |
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Oscar Della Pasqua GSK |