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DDMoRe: past, present and future

Lutz Harnisch's picture

Today, we’ve reached a turning point for the DDMoRe consortium.  The main products have been developed and much of the content we promised to release is in the public domain.  Now it’s time to promote the added benefit the repository and the framework will bring to modellers around the world.
It hasn’t been an easy task, but over the last 5 years an enthusiastic group of developers and key stakeholders from the PKPD modelling community have pulled the puzzle together.  We have proved that it is possible to design new languages and standards with modellers and models of different provenances talking to each other, allowing for a nearly unconstrained exchange of information, context and knowledge within a model-informed framework that has not been seen before.
Certainly development can never be complete – there will always be inconsistencies in collaborative thinking and implementation – but the framework and the repository have reached an impressive level of maturity, allowing us to now engage with a wider audience in a very practical, hands-on way to show the value DDMoRe brings to many stakeholders.
I’m sure we’ll manage to fill the final gaps during the last few months before the IMI life cycle comes to an end.  After that the consortium will evolve into the DDMoRe Foundation, ensuring long-term sustainability of its achievements, and a new lifecycle of further developments can be initiated.
What has been accomplished is crystal clear: an easily accessible, searchable content rich library of models enabling analysts around the world to access their co-workers’ modelling outputs, if they are safely stored in the repository at and have achieved a comprehensive qualification to ensure their reproducibility. The modelling framework is in place (it can be downloaded at and is under testing with many colleagues to give it the nearly final form and shape.
Since the beginning, DDMoRe’s activities have been accompanied by associated training efforts.  Beyond the many classroom training courses given at academic centers around Europe, multi-media materials have been produced to reach a wider audience and a full day workshop at PAGE in Lisbon this June will provide insights into all aspects that DDMoRe has touched.
Over the past 5 years the DDMoRe consortium established an unequaled collaboration among modellers.  We hope that this fruitful partnership will be nurtured further through the Foundation taking its place in a few months.

Lutz Harnisch - coordinator DDMoRe
Further information:
Harnisch L et al. (2013) Drug and Disease Model Resources: A Consortium to Create Standards and Tools to Enhance Model-Based Drug Development. CPT: Pharmacometrics & Systems Pharmacology (2013) 2, e34; doi:10.1038/psp.2013.10;