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AAPS/EUFEPS Joint Symposium: Collaborative Drug and Disease Model Building

Oct 25 to Oct 29, 2015

United States

AAPS/EUFEPS Joint Symposium: Collaborative Drug and Disease Model Building

Meindert Danhof Ph.D.
Ted Grasela Ph.D.

Proposal Description:
Modern drug discovery and development relies increasingly on modeling and simulation. In the past decades, population pharmacokinetic and pharmacodynamic modeling has been introduced to improve the understanding of intra- and inter-individual variation in the treatment response upon administration of a drug. Here increasingly mechanistic models are used, which are based on concepts of physiologically-based pharmacokinetic (PBPK) modeling and mechanism-based pharmacokinetic-pharmacodynamic (MBPKPD) modeling, and which have a much improved value for extrapolation and prediction. More recently this modeling has been complemented with the modeling of disease processes and disease progression in drug development. Integration of the aforementioned modeling exercises constitutes a basis for the development multi-scale drug and disease models that serve as the scientific basis for the design and the development of novel therapeutic interventions. The development of such multi-scale models relies on the availability of large databases, which typically may not be available within single institutions. This has prompted a number of initiatives for data-sharing both in the United States and in Europe. The purpose of this session is to bring participants in these initiatives from the U.S. and Europe together to share experiences and discuss the scientific, legal and practical aspects of data sharing in the context of collaborative drug and disease model building.

Presentation by Mats Karlsson Scientific Manager DDMoRe - 29th of October 9:40 AM–10:25 AM

Drug and Disease Model Resources (DDMoRe)—A Framework for Model Sharing and Software Interoperability

OCCC - Room W308


Associated members

Mats Karlsson's picture
Mats Karlsson
Uppsala Universitet

Related links

AAPS - American Association of Pharmaceutical Scientists

ACoP - American Conference on Pharmacometrics

COMBINE - The 'COmputational Modeling in BIology' NEtwork

EARL - EARL conference; effective application of the R language

ISoP - International Society of Pharmacometrics

PAGANZ - Population Approach Group of Australia and New Zealand

PAGE - Population Appraoch Group in Europe

PharmacoMetrica - PharmacoMetrica workshop

PKUK - Pharmacokinetics (UK)

WCoP - World Conference on Pharmacometrics