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Review of Mixed-Effects Models of Tumor Growth in CPT: PSP

A Review of Mixed-Effects Models of Tumor Growth and Effects of Anticancer Drug Treatment Used in Population Analysis.

B Ribba, NH Holford, P Magni, I Trocóniz, I Gueorguieva, P Girard, C Sarr, M Elishmereni, C Kloft and LE Friberg CPT:Pharmacometrics and Systems Pharmacology, 2014, e113


Population modeling of tumor size dynamics has recently emerged as an important tool in pharmacometric research. A series of new mixed-effects models have been reported recently, and we present herein a synthetic view of models with published mathematical equations aimed at describing the dynamics of tumor size in cancer patients following anticancer drug treatment. This selection of models will constitute the basis for the Drug Disease Model Resources (DDMoRe) repository for models on oncology.


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Associated members

Celine Sarr's picture
Celine Sarr
Ivelina Gueorguieva's picture
Ivelina Gueorguieva
Eli Lilly
Pascal Girard's picture
Pascal Girard
Charlotte Kloft's picture
Charlotte Kloft
Freie Universität Berlin - FUB
Iñaki Troconiz's picture
Iñaki Troconiz
University of Navarra
Lena Friberg's picture
Lena Friberg
Uppsala Universitet
Nick Holford's picture
Nick Holford
Uppsala Universitet
Paolo Magni's picture
Paolo Magni
Universita' degli Studi di Pavia
Moran Elishmereni's picture
Moran Elishmereni