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Exchange Standards

Standards to facilitate seamless exchange

A unified Model Description Language (MDL) has been developed. It has been designed to be easily read and written by modellers. It is expected that it will facilitate easy uptake by modellers already experienced in other modelling languages.

The XML-based Pharmacometrics Markup Language (PharmML) a new exchange format for encoding of models, associated tasks and their annotation as used in pharmacometrics.

Its connected metadata framework is based on standard reference ontologies, build on existing community exchange protocols such as the CDISC clinical data standards and CSHARE framework.

The Standard Output (SO) has been developed as a tool-independent exchange XML-based format for storing results in standardised form. It enables effective data exchange within complex workflows as well as supports users in assessing, reviewing and reporting modelling steps.


  • Project posted on 5 years 2 weeks ago

    ProbOnto is a knowledge base and ontology of probability distributions. It was designed to facilitate the encoding of nonlinear-mixed effect models and their annotation in PharmML developed by DDMoRe... Read more

  • News posted on 5 years 1 month ago

    Leiden, The Netherlands, 22nd of August 2016 – The Modelling & Simulation community is poised to benefit from the first fully integrated open-source modelling environment, proudly released by the... Read more

  • Project posted on 5 years 6 months ago

    Standard Output (SO) SO is a tool-independent exchange XML-based format, intended for storage of results in standardised form. It enables effective data exchange within complex workflows as well as... Read more

  • Timeline posted on 5 years 10 months ago

    Model Description Language MDL is a human writeable and human readable language designed to describe pharmacometric models. It is intended to be largely agnostic about the choice of target tool. MDL... Read more

  • News posted on 6 years 4 months ago

    Leiden, The Netherlands, 3rd of June 2015 – PharmML, a flexible format for exchanging computational models in pharmaceutical R&D, opens new opportunities for drug discovery and clinical research... Read more

  • Timeline posted on 6 years 8 months ago

    Pharmacometric Markup Language (PharmML) XML based format, PharmML for storing and exchange of pharmacometrics models and associated results.  PharmML provides means to encode - mathematical/... Read more