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The objective of Work Package 1 is to prepare and incorporate a selection of approved models into the model repository. The models will be presented with their collection of appropriate metadata like data availability, model qualification and contextual information. This selection will cover therapeutic areas of diabetes, oncology and other diseases (schizophrenia, inflammatory and neurodegenerative disorders, pain, virology and generic safety). Representative models covering systems biology, PK-PD, disease progression, and clinical outcome (amongst others) relevant to the different stages in drug development will be considered.

Models will be integrated into the model repository and will be coded using the model description language. WP1 will provide a proof of concept for the model repository, languages and framework.

Main outcomes of WP1

  • Selection of relevant models in the therapeutic areas.
  • Encoded implementations of the models and a report of possible problems of consistency.
  • Implementation of the models into the model repository using DDMoRe’s ontologies and standards.
  • Proof the functionality of the model repository.
  • Dissemination of these models to the community.


  • Events posted on 7 years 2 months ago

    September 5 - 9; Washington D.C, USA 54th Interscience Conference on Antimicrobial Agents and Chemotherapy, ICAAC. The Conference is going to be located at the Walter E. Washington Convention Center... Read more

  • News posted on 7 years 3 months ago

    Modeling of 24-Hour Glucose and Insulin Profiles in Patients With Type 2 Diabetes Mellitus Treated With Biphasic Insulin Aspart. Rikke M. Røge, Søren Klim, Niels R. Kristensen, Steen H. Ingwersen,... Read more

  • News posted on 7 years 4 months ago

    A Review of Mixed-Effects Models of Tumor Growth and Effects of Anticancer Drug Treatment Used in Population Analysis. B Ribba, NH Holford, P Magni, I Trocóniz, I Gueorguieva, P Girard, C Sarr, M... Read more

  • News posted on 7 years 5 months ago

    A Population Pharmacodynamic Model for Lactate Dehydrogenase and Neuron Specific Enolase to Predict Tumor Progression in Small Cell Lung Cancer Patients Núria Buil-Bruna, José-María López-Picazo,... Read more

  • News posted on 7 years 7 months ago

    Longitudinal Modeling of the Relationship Between Mean Plasma Glucose and HbA1c Following Antidiabetic Treatments JB Møller, RV Overgaard, MC Kjellsson, NR Kristensen, S Klim, SH Ingwersen and MO... Read more

  • News posted on 7 years 10 months ago

    Population pharmacokinetic pharmacodynamic modelling in oncology: a tool for predicting clinical response1 B C Bender, E Schindler, L E Friberg. Br. J. Clin. Pharmacol. Abstract In oncology trials,... Read more

  • News posted on 7 years 10 months ago

    Modeling tumor response after combined administration of different immune-stimulatory agents. Parra-Guillen ZP, Berraondo P, Ribba B, Trocóniz IF. JPET AbstractThe aims of this work were as follows:... Read more

  • News posted on 7 years 10 months ago

    Mathematical Model Approach to Describe Tumour Response in Mice After Vaccine Administration and its Applicability to Immune-Stimulatory Cytokine-Based Strategies. Zinnia P. Parra-Guillen, Pedro... Read more

  • News posted on 8 years 1 week ago

    Pharmacokinetic-pharmacodynamic modeling of antibacterial drugs. Nielsen EI, Friberg LE. Pharmacol. Rev.  AbstractPharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an... Read more

  • Events posted on 8 years 2 months ago

    September 23 - 27,  Spain European Association for the study of diabetes (EASD), at their 49th annual meeting two posters will be presented on diabetes models supported by DDMoRe.