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The interoperable Modelling Markup Languages (MMLs) will provide the representation standards and ontologies of the data and associated metadata. These MMLs will be based on existing languages and will be evaluated for their interoperability with developed and considered clinical (CDISC) and pharmaceutical (PISTOIA alliance) standards.

Main outcome of WP4

  • Specification of MMLs based on DDMoRe community requirements for data and models used in pharmacometrics
  • Creation of a system-­to­‐system standard for data, models and metadata interchangeability and the key­‐element for the interoperability within the DDMoRe framework
  • Establishing MML as Lingua franca for the exchange between tools in population PK, such as Monolix, NONMEM or WinBUGS
  • Reuse of existing standards such as SBML, SED-­ML, UncertML, PharmML and PMML
  • Accessibility of MML via an Application Programming Interface, API


  • Project posted on 5 years 2 weeks ago

    ProbOnto is a knowledge base and ontology of probability distributions. It was designed to facilitate the encoding of nonlinear-mixed effect models and their annotation in PharmML developed by DDMoRe... Read more

  • News posted on 5 years 1 month ago

    Leiden, The Netherlands, 22nd of August 2016 – The Modelling & Simulation community is poised to benefit from the first fully integrated open-source modelling environment, proudly released by the... Read more

  • Project posted on 5 years 6 months ago

    Standard Output (SO) SO is a tool-independent exchange XML-based format, intended for storage of results in standardised form. It enables effective data exchange within complex workflows as well as... Read more

  • Mar 17 to Mar 18, 2016
    United Kingdom
    Events posted on 5 years 7 months ago

    Location: GSK House, 980 Great West Rd, Brentford, London, Middlesex TW8 9GS Date: 17th March (from 12:00) – 18th March (until last man standing) Transport links from... Read more

  • News posted on 6 years 4 months ago

    Leiden, The Netherlands, 3rd of June 2015 – PharmML, a flexible format for exchanging computational models in pharmaceutical R&D, opens new opportunities for drug discovery and clinical research... Read more

  • Timeline posted on 6 years 8 months ago

    Pharmacometric Markup Language (PharmML) XML based format, PharmML for storing and exchange of pharmacometrics models and associated results.  PharmML provides means to encode - mathematical/... Read more

  • News posted on 7 years 3 months ago

    Biophysical constraints on the evolution of tissue structure and function. P. J. Hunter and B. de Bono Abstract Phylogenetic analyses based on models of molecular sequence evolution have driven to... Read more

  • News posted on 7 years 10 months ago

    Leiden, the Netherlands, 20th December 2013 – The IMI Drug Disease Model Resources (DDMoRe) consortium is launching modelling languages to enable quantitative decision making across all stages of... Read more

  • Events posted on 8 years 1 week ago

    October 30-31 2013, Brussels, Belgium The workshop is jointly organised by partners on IMI projects DDMoRe, OpenPHACTS and eTox, and hosted by the Innovative Medicines Initiative (IMI). This event... Read more

  • News posted on 8 years 1 week ago

    Functional tissue units and their primary tissue motifs in multi-scale physiology. Bernard de Bono, Pierre Grenon, Richard Baldock, Peter Hunter JBiomedSemantics Abstract Background Histology... Read more