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The interoperable Modelling Markup Languages (MMLs) will provide the representation standards and ontologies of the data and associated metadata. These MMLs will be based on existing languages and will be evaluated for their interoperability with developed and considered clinical (CDISC) and pharmaceutical (PISTOIA alliance) standards.

Main outcome of WP4

  • Specification of MMLs based on DDMoRe community requirements for data and models used in pharmacometrics
  • Creation of a system-­to­‐system standard for data, models and metadata interchangeability and the key­‐element for the interoperability within the DDMoRe framework
  • Establishing MML as Lingua franca for the exchange between tools in population PK, such as Monolix, NONMEM or WinBUGS
  • Reuse of existing standards such as SBML, SED-­ML, UncertML, PharmML and PMML
  • Accessibility of MML via an Application Programming Interface, API


  • Timeline posted on 8 years 2 months ago

    PharmML PharmML stands for Pharmacometrics Markup Language. This is the first public release of a new standard for encoding of models, associated tasks and their annotation as used in pharmacometrics... Read more

  • Events posted on 9 years 1 month ago

    August 15 - 19, Canada The "Computational Modeling in Biology" Network (COMBINE) is an initiative to coordinate the development of the various community standards and formats in systems biology and... Read more

  • Events posted on 9 years 4 months ago

    May 20 - 25, The Netherlands The Hackathons on Resources for Modeling in Biology (HARMONY) is a series of hackathon-type meetings, with a focus on development of the standards, interoperability and... Read more

  • Events posted on 9 years 5 months ago

    April 16 - 20, Sweden State of the IMI Projects presented by Bernard de Bono, EMBL - EBI

  • News posted on 9 years 7 months ago

    ApiNATOMY: a novel toolkit for visualizing multiscale anatomy schematics with phenotype-related information. Bernard de Bono, Pierre Grenon and Stephen John Sammut. Hum. Mutat. 2012, 33: 837... Read more

  • News posted on 9 years 9 months ago

    The RICORDO approach to semantic interoperability for biomedical data and models: strategy, standards and solutions. Bernard de Bono, Robert Hoehndorf, Sarala Wimalaratne, George Gkoutos and Pierre... Read more