Interoperability Framework

DDMoRe, sharing knowledge to improve drug development

The Drug Disease Model Resources (DDMoRe) consortium has been created to improve the quality, efficiency and cost effectiveness of model-informed decisions in drug development and therapeutic use of marketed drugs.

The platform will deliver consistency of evidence that industry and health authorities can rely on in making decisions about development and approval of new medicines. It will also be a resource for academic research and improvement of therapy with existing drugs. Information from a wide array of sources can be integrated into models to describe and predict the behavior of complex disease/biological systems and drug actions.


DDMoRe’s products

DDMoRe’s products deliver an open source, integrated framework to enable Model Informed Drug Discovery & Development:

An open, publicly available, free-to-use model repository. Based on the developed standards Pharmacomtrics Markup Language and Modelling Description Language, the repository will enable sharing and re-use of models.

An integrated infrastructure to enable efficient exchange and integration of models across modelling languages, existing and new tools.

Education and training in DDMoRe’s products and their use in drug/disease Modelling and Simulation.

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PSPod for DDMoRe by coordinator Lutz Harnisch

The Drug Disease Model Resources (DDMoRe): A Consortium to Create Standards and Tools to Enhance Model-Based Drug Development This episode features Lutz Harnisch from Clinical Pharmacology Pharmacometrics at Pfizer, discussing the Drug Disease Model Resources (DDMoRe) consortium. His Perspective article that introduces the activities of the DDMoRe consortium...

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