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DDMoRe, sharing knowledge to improve drug development

The Drug Disease Model Resources (DDMoRe) consortium has been created to improve the quality, efficiency and cost effectiveness of model-informed decisions in drug development and therapeutic use of marketed drugs.

The platform will deliver consistency of evidence that industry and health authorities can rely on in making decisions about development and approval of new medicines. It will also be a resource for academic research and improvement of therapy with existing drugs. Information from a wide array of sources can be integrated into models to describe and predict the behavior of complex disease/biological systems and drug actions.


DDMoRe’s products

DDMoRe’s products deliver an open source, integrated framework to enable Model Informed Drug Discovery & Development:


Model Repository

An open, publicly available, free-to-use model repository. Based on the developed standards Pharmacomtrics Markup Language and Modelling Description Language, the repository will enable sharing and re-use of models.


Model Certification

A shared definition of model quality standards.


Interoperability Framework

An integrated infrastructure to enable efficient exchange and integration of models across modelling languages, existing and new tools.

New tools: Simulx is a function of the R package mlxR. Simulx allows one to simulate complex models for longitudinal data by interfacing the C++ MlxLibrary with R.


Exchange standards

Pharmacometrics Markup Language; PharmML or www.pharmml.org a new exchange format for encoding of models, associated tasks and their annotation as used in pharmacometrics. Modelling Description Language; MDL


Pharmacometric workflow

Reproducible processes to drive efficiency and effectiveness in modeling tasks.



UPCOMING NEW DDMoRe TRAINING Read more and apply now!

Support education and training in DDMoRe’s products and their use in drug/disease Modelling and Simulation


DDMoRe members


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