About DDMoRe

The Drug Disease Model Resources (DDMoRe) consortium builds and maintains a universally applicable, open source, model based framework, intended as the gold standard for future collaborative drug and disease Modelling & Simulation.

Modelling and Simulation (M&S) is a technology providing the quantitative basis for informed decision making across all stages of pharmaceutical drug development. This model-based drug development is accepted as a vital approach in understanding patients’ drug-related benefit and risk. Information from a wide array of sources to describe and predict the behaviours of complex disease/biological systems and drug actions can be integrated in models.

Before the DDMoRe consortium, a lack of common tools, languages and ontologies for M&S limited the access to stored information which created significant gaps in the way knowledge could be exploited within drug development.  The DDMoRe consortium is generating a public drug and disease model repository as well as an open source interoperability framework containing standards and tools to cover the identified gaps in the M&S software ecosystem. The DDMoRe project’s standards and tools – intended as the gold standard for future collaborative drug and disease M&S - will be supported by comprehensive training and will be made publicly accessible.

Key Objectives

• Enable efficient exchange and integration of modelling activities.
• Outputs across software tools, disciplines and departments within and among organizations.
• Provide standards applicable to all areas of M&S, appropriate for adoption and use by all relevant domain stakeholders.
• Development of an open, publicly available, free-to-use model repository, based on the developed standards, to promote the re-use of models.
• The model repository may evolve into a global reference for model-based efforts in the therapeutic areas Diabetes, Oncology and Other Diseases.
• Provide support for education and training in drug/disease M&S.