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Beta-release Interoperability Framework

Dec 11 2015

The Beta-release of the Interoperability Framework is available now for download.

Supported features

A high-level overview of the features available in the beta version is provided in the list of Supported Features.
To install the Interoperability Framework, please use the instructions in the Installation Guide.
NOTE: In order to use NONMEM within the Interoperability Framework, you need to obtain the NONMEM binaries from ICON. You can also obtain a temporary licence from ICON, if you don’t already have one. If you do already have a NONMEM license, you are allowed to use it within the Interoperability Framework under the conditions specified in the Installation Guide. The process for requesting and installing the NONMEM binaries (and a temporary license, if needed) is described in Section 8 and Section 9.1 of the Installation Guide. The temporary license obtained from ICON will expire after approx. 45 days of use, but you can then apply for a full commercial licence by sending an email request to
NOTE: In order to use Monolix and Simulx, a temporary license is included within the Interoperability Framework.   When launching the Interoperability Framework, you may be prompted to enter an “Activation Key'' (for LIXOFT - Simulator).  If so, you will need to enter the location of the Lixoft license file (<SEE-HOME>\Monolix432s\bin\Monolix_mcr\runtime\config\system\access\ddmore.lic). The temporary license will expire on February 1st 2016, but you can then apply for a full commercial license by sending an email request to

For more help on installation, please see our installation instruction video.
Please also see the Release Note.

Testing the installation
Full instructions on validation of your installation can be found in the section ‘Verification of Software Installation’ in the Installation Guide

For a guided tour of the InstallationTest script, please see our Installation Test instruction video.
Working with the framework and models in MDL
Before you start encoding models in MDL and using the framework, please see our Introduction to MDL instruction video and take a look at the MDL User Guide and Reference Manual.

Further details on starting to use MDL models with the Interoperability Framework (including a number of ‘real-world’ examples) can be found in the section ‘What next?’ in the Installation Guide.

Also included in the ‘UseCasesDemo’ project are R scripts, which demonstrate the functionality of the tools provided with the framework for each of the UseCase examples. We encourage you to take a look at these and try running them. HTML files with reference results for each of the R scripts are available here for comparison (see download at this page).

Known issues
As development of the Interoperability Framework is ongoing, some issues and bugs remain in the beta version. Please check the list of Known Issues for an overview of these.
More information, questions and feedback
If you have questions about the Interoperability Framework or about some of the terms and abbreviations used, please take a look at our FAQs  or our Glossary.
If you cannot find an answer there, please check out our forum and post your question there.