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PAGE meeting - Lisboa 2016

Jun 07 to Jun 10, 2016

University of Lisbon Rectory
Alameda da Universidade
1649-004 Lisboa

DDMoRe will present a free one day workshop on the 7th of June entitled

"Get inspired … get started … get into the world of DDMoRe".
This workshop will consist of presentations and hands-on session with DDMoRe products and runs from 9:00 to 18:00 PM
Auditorium “A” of the Faculty of Pharmacy.
Av. Prof. Gama Pinto, 1649-003 Lisboa, Portugal
It is located at walking distance from the meeting venue.

9:00 - 9:15 General introduction
9:15 - 9:45 Interoperability Framework introduction
9:45 - 10:15 Intro to Model Description Language (MDL)

Coffee break

10:30 - 11:00 MDL continued
11:00 - 12:00 Interoperability Framework hands-on session
12:00 - 12:30 Exchange standards


13:30 - 14:00 Model Repository, Qualification procedure and Annotations
14:00 - 15:00 Model Repository: browse / explore / download / use models

Coffee break

15:15 - 16:15 Introduction to MID3 Thoughtflow: standards and tools
16:15 - 16:45 DDMoRe created new tools and integrating future tools
16:45 - 17:15 What is the future: DDMoRe Foundation
17:15 - 18:00 Wrap-up

All these products together deliver the DDMoRe platform, which will be demonstrated live with real model examples, showing the different elements and intended workflows. The added value of the products to efficiently apply model-based approaches and knowledge exchange - supporting the concept Model Informed Drug Discovery and Development (MID3)  - will be discussed in the closing session of the workshop. 

PAGE abstracts:

  1. A new language for complex ODE models. Michael Dunlavey, Shuhua Hu, Robert Leary
  2. A comparison of different model-based approaches to scale preclinical to clinical tumour growth inhibition in gemcitabine-treated pancreatic cancer. Maria Garcia-Cremades, Celine Pitou, Philip W Iversen, Iñaki F Troconiz
  3. Pharmacometrics workflow: standards for provenance capture and workflow definition. Jonathan Chard, Justin Wilkins, Amy Cheung, Evan Wang, Mike K. Smith, Phylinda Chan, Gareth Smith, Richard Kaye, Maria Luisa Sardu, Stuart Moodie
  4. Methods and tools for multiscale modelling in Systems Pharmacology: a review. Borella Elisa, Carrara Letizia, Lavezzi Silvia Maria, Massaiu Ilaria, Sauta Elisabetta, Tosca Elena Maria, Vitali Francesca, Zucca Susanna, Pasotti Lorenzo, De Nicolao Giuseppe, Magni Paolo
  5. Model-based optimal robust design in pharmacometrics. Giulia Lestini, Sebastian Ueckert, France Mentré
  6. Simcyp Simulator within the DDMoRe Interoperability Framework - Proof of Concept Cases. Khaled Abduljalil, Craig Lewin, Adrian Barnett, Steve Marciniak, Masoud Jamei
  7. Development and integration of the WinBUGS connector in the DDMoRe Interoperability Framework. Cristiana Larizza, Elisa Borella, Lorenzo Pasotti, Gareth Smith, Richard Kaye, Paolo Magni
  8. Evaluation of a PK/PD DEB-based model for tumor-in-host growth kinetics under anticancer treatment. Elena Maria Tosca, Elisa Borella, Nadia Terranova, Maurizio Rocchetti, Paolo Magni
  9. Model Description Language (MDL) - a standard for model communication and interoperability. M.K. Smith, S. Moodie, R. Bizzotto, E. Blaudez, E. Borella, L. Carrara, P. Chan, M. Chenel, E. Comets, R. Gieschke, K. Harling, L. Harnisch, N. Hartung, A. Hooker, M.O. Karlsson, R. Kaye, C. Kloft, N. Kokash, M. Lavielle, P. Magni, A. Mari, F. Mentre, C. Muselle, R. Nordgren, H. Nyberg, Z.P. Parra-Guillen, L. Pasotti, N. Rode-Kristensen, G. Smith, M.J. Swat, N. Terranova, F. Yvon, N. Holford
  10. Modelling of classified individual tumor lesions in metastatic colorectal cancer (mCRC) patients using delay differential equations. M.L. Sardu, N. Terranova, P. Girard, A. Munafo
  11. Capacities of NPDE, VPC and pvcVPC at detecting model misspecification: a simulation study of a PK model showed no apparent difference. Anaïs Glatard, Thomas Dumortier, Jean-Louis Steimer, Céline Sarr
  12. PsN and Xpose. Kajsa Harling, Andrew C. Hooker, Rikard Nordgren, Mats O. Karlsson
  13. PharmML & SO - standards for encoding models and results in PMX and QSP. Maciej J. Swat, Nadia Terranova, on behalf of all DDMoRe contributors
  14. Dismounting Saddles on the Likelihood Surface. Henrik Bjugård Nyberg, Andrew C. Hooker, Yasunori Aoki
  15. Robust QT prolongation assessment using model-averaging. Anne-Gaëlle Dosne, Martin Bergstrand, Mats O. Karlsson, Didier Renard, Günter Heimann



Associated members

Celine Sarr's picture
Celine Sarr
Lutz Harnisch's picture
Lutz Harnisch
Mike K Smith's picture
Mike K Smith
Peter Milligan's picture
Peter Milligan
Charlotte Kloft's picture
Charlotte Kloft
Freie Universität Berlin - FUB
Maciej Swat's picture
Maciej Swat
EMBL - European Bioinformatics Institute
Mats Karlsson's picture
Mats Karlsson
Uppsala Universitet
Wendy Aartsen's picture
Wendy Aartsen
Leiden University
Zinnia Parra-Guillén's picture
Zinnia Parra-Guillén
Jonathan Chard's picture
Jonathan Chard
Mango Business Solutions

Related links

AAPS - American Association of Pharmaceutical Scientists

ACoP - American Conference on Pharmacometrics

COMBINE - The 'COmputational Modeling in BIology' NEtwork

EARL - EARL conference; effective application of the R language

ISoP - International Society of Pharmacometrics

PAGANZ - Population Approach Group of Australia and New Zealand

PAGE - Population Appraoch Group in Europe

PharmacoMetrica - PharmacoMetrica workshop

PKUK - Pharmacokinetics (UK)

WCoP - World Conference on Pharmacometrics