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Official Release - Interoperability Framework

Aug 22 2016

The official release of the Interoperability Framework is now available for download.
Supported features
A high-level overview of the features available in the Interoperability Framework is provided in the list of Supported Features.
To install the Interoperability Framework, please use the instructions in the Installation Guide.
NOTE: In order to use NONMEM within the Interoperability Framework, you need to obtain the NONMEM binaries from ICON. You can also obtain a temporary licence from ICON, if you don’t already have one. If you do already have a NONMEM license, you are allowed to use it within the Interoperability Framework under the conditions specified in the Installation Guide. The process for requesting and installing the NONMEM binaries (and a temporary license, if needed) is described in Section 8 and Section 9.1 of the Installation Guide. The temporary license obtained from ICON will expire after approx. 45 days of use, but you can then apply for a full commercial licence by sending an email request to
NOTE: In order to use Monolix and MlxLibrary (used for Simulx), a temporary license is included within the Interoperability Framework. The temporary license will expire on October 30th 2016, but you can then apply for a full commercial license at Please see for instructions on how to install a new license (or use your own commercial license, if you already have one).

For more help on installation, please see our Installation instruction video.
Please also see the Release Note.
Testing the installation
Full instructions on validation of your installation can be found in the section ‘Verification of Software Installation’ in the Installation Guide. For a guided tour of the InstallationTest script, please see our Installation Test instruction video.
Working with the framework and models in MDL
Before you start encoding models in MDL and using the framework, please see our MDL instruction video and take a look at the MDL User Guide and Reference Manual. For more technical details of MDL, please see the MDL Reference.

Included in the framework distribution is a ‘UseCasesDemo’ project, which shows UseCase examples of models encoded in MDL. All of these models represent valid MDL and can be converted to PharmML, but not all of the models can be further converted for execution in target tools. Also included in the ‘UseCasesDemo’ project are R scripts, which demonstrate the functionality of the tools provided with the framework for the UseCase examples, which can be further converted for execution in target tools and how to retrieve the Standard Output (SO) object generated after each task execution. More information about these UseCase examples is available in a ReadMe.pdf file. We encourage you to take a look at the R scripts and try running them. HTML files with reference results for each of the R scripts are available for comparison.
Known issues
Some issues and bugs remain in the released version of the Interoperability Framework. Please check the list of Known Issues for an overview of these.
More information, questions and feedback
If you have questions about the Interoperability Framework or about some of the terms and abbreviations used, please take a look at our FAQs  or our Glossary.
If you cannot find an answer there, please check out our forum and post your question there.

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